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KMID : 0370220200640040290
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Yakhak Hoeji
2020 Volume.64 No. 4 p.290 ~ p.298
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National Research and Development Trends related to Safety Evaluation Technology of Biologics and Chemical Synthetic Drug: A Network Analysis
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Jang Suk-Chan
Lee Sang-Won
Kwon Sun-Hong
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Abstract
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It is important to compare the differences in safety evaluation trends of chemical drugs, which have beenmainstream in the existing pharmaceutical field, and emerging biologic drugs. Therefore, this study conducted networkanalyses on government-granted Research and Development (R&D) projects across biopharmaceuticals and chemicalsyntheticdrugs. Information on research projects conducted between 2002 and 2017 was extracted from the NationalScience and Technology Information Service. The projects were categorized into four groups (2002-2006, 2007-2011,2012-2016, and 2017). We visualized networks using NetMiner ver.4 (Cyram Inc). The research on biologics increasedfrom 593 projects in 2002-2006 to 2,001 projects in 2012-2016; those on synthetic drugs increased from 3,376 projectsto 4,741. The network for biologics becomes complicated by not only focusing on evaluation technology but connectingwith safety and use while the network for synthetic drugs gets simple with centered knots of safety and use. For both,researches related to evaluation technology have been increasing. To establish appropriate regulatory policies for biologics,a blueprint of R&D covering evaluation technology, safety, and use needs to be planned.
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KEYWORD
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network analysis, pharmaceutical evaluation technology, biologic drug, chemical synthetic drug
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